Uncovering Zn(2+) as a cofactor of FAD-dependent Pseudomonas aeruginosa PAO1 d-2-hydroxyglutarate dehydrogenase

Pseudomonas aeruginosa couples the oxidation of d-2-hydroxyglutarate (D2HG) to l-serine biosynthesis for survival, using d-2-hydroxyglutarate dehydrogenase from P. aeruginosa (PaD2HGDH). Knockout of PaD2HGDH impedes P. aeruginosa growth, making PaD2HGDH a potential target for therapeutics. Previous...

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Detalles Bibliográficos
Autores principales: Quaye, Joanna A., Gadda, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025160/
https://www.ncbi.nlm.nih.gov/pubmed/36775126
http://dx.doi.org/10.1016/j.jbc.2023.103007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025160/
https://www.ncbi.nlm.nih.gov/pubmed/36775126
http://dx.doi.org/10.1016/j.jbc.2023.103007

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