Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation

The mode of action (MoA) of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicides in mammals is well described and is generally accepted to be due to a build-up of excess systemic tyrosine which is associated with the range of adverse effects reported in laboratory animals. What is les...

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Detalles Bibliográficos
Autores principales: Botham, Jane, Lewis, Richard W., Travis, Kim Z., Baze, Audrey, Richert, Lysiane, Codrea, Elizabeth, Semino Beninel, Giovanna, Garcin, Jean-Christophe, Strupp, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Regulatory Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025182/
https://www.ncbi.nlm.nih.gov/pubmed/36800004
http://dx.doi.org/10.1007/s00204-023-03458-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025182/
https://www.ncbi.nlm.nih.gov/pubmed/36800004
http://dx.doi.org/10.1007/s00204-023-03458-8

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