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Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation

The mode of action (MoA) of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicides in mammals is well described and is generally accepted to be due to a build-up of excess systemic tyrosine which is associated with the range of adverse effects reported in laboratory animals. What is les...

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Detalles Bibliográficos
Autores principales:	Botham, Jane, Lewis, Richard W., Travis, Kim Z., Baze, Audrey, Richert, Lysiane, Codrea, Elizabeth, Semino Beninel, Giovanna, Garcin, Jean-Christophe, Strupp, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Regulatory Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025182/ https://www.ncbi.nlm.nih.gov/pubmed/36800004 http://dx.doi.org/10.1007/s00204-023-03458-8

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