Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice

Pdia4 has been characterized as a key protein that positively regulates β-cell failure and diabetes via ROS regulation. Here, we investigated the function and mechanism of PS1, a Pdia4 inhibitor, in β-cells and diabetes. We found that PS1 had an IC(50) of 4 μM for Pdia4. Furthermore, PS1 alone and i...

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Detalles Bibliográficos
Autores principales: Tseng, Hui-Ju, Chen, Wen-Chu, Kuo, Tien-Fen, Yang, Greta, Feng, Ching-Shan, Chen, Hui-Ming, Chen, Tzung-Yan, Lee, Tsung-Han, Yang, Wen-Chin, Tsai, Keng-Chang, Huang, Wei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025235/
https://www.ncbi.nlm.nih.gov/pubmed/36935456
http://dx.doi.org/10.1007/s00018-022-04677-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025235/
https://www.ncbi.nlm.nih.gov/pubmed/36935456
http://dx.doi.org/10.1007/s00018-022-04677-5

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