Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst

Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quantitative technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcohols as alkylating agents and an NHC-Ir(III) catalyst. We detail specific steps for...

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Detalles Bibliográficos
Autores principales: Saavedra, Beatriz, Bermejo-López, Aitor, Raeder, Majken, Martín-Matute, Belén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025274/
https://www.ncbi.nlm.nih.gov/pubmed/36920910
http://dx.doi.org/10.1016/j.xpro.2023.102147
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author Saavedra, Beatriz
Bermejo-López, Aitor
Raeder, Majken
Martín-Matute, Belén
author_facet Saavedra, Beatriz
Bermejo-López, Aitor
Raeder, Majken
Martín-Matute, Belén
author_sort Saavedra, Beatriz
collection PubMed
description Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quantitative technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcohols as alkylating agents and an NHC-Ir(III) catalyst. We detail specific steps for catalyst preparation and application, as well as for catalyst recycling. The protocol excludes a few amino acids (l-cysteine, l-lysine, and l-arginine) and secondary alcohols. For complete details on the use and execution of this protocol, please refer to Bermejo-López et al. (2022).(1)
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spelling pubmed-100252742023-03-21 Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst Saavedra, Beatriz Bermejo-López, Aitor Raeder, Majken Martín-Matute, Belén STAR Protoc Protocol Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quantitative technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcohols as alkylating agents and an NHC-Ir(III) catalyst. We detail specific steps for catalyst preparation and application, as well as for catalyst recycling. The protocol excludes a few amino acids (l-cysteine, l-lysine, and l-arginine) and secondary alcohols. For complete details on the use and execution of this protocol, please refer to Bermejo-López et al. (2022).(1) Elsevier 2023-03-14 /pmc/articles/PMC10025274/ /pubmed/36920910 http://dx.doi.org/10.1016/j.xpro.2023.102147 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Saavedra, Beatriz
Bermejo-López, Aitor
Raeder, Majken
Martín-Matute, Belén
Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title_full Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title_fullStr Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title_full_unstemmed Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title_short Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
title_sort selective quantitative n-functionalization of unprotected α-amino acids using nhc-ir(iii) catalyst
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025274/
https://www.ncbi.nlm.nih.gov/pubmed/36920910
http://dx.doi.org/10.1016/j.xpro.2023.102147
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