Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome

Aicardi-Goutières syndrome (AGS1-9) is a genetically determined encephalopathy that falls under the type I interferonopathy disease class, characterized by excessive type I interferon (IFN-I) activity, coupled with upregulation of IFN-stimulated genes (ISGs), which can be explained by the vital role...

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Detalles Bibliográficos
Autores principales: Withers, Sarah E., Rowlands, Charlie F., Tapia, Victor S., Hedley, Frances, Mosneag, Ioana-Emilia, Crilly, Siobhan, Rice, Gillian I., Badrock, Andrew P., Hayes, Andrew, Allan, Stuart M., Briggs, Tracy A., Kasher, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025490/
https://www.ncbi.nlm.nih.gov/pubmed/36949945
http://dx.doi.org/10.3389/fimmu.2023.1100967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025490/
https://www.ncbi.nlm.nih.gov/pubmed/36949945
http://dx.doi.org/10.3389/fimmu.2023.1100967

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