hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration

BACKGROUND: Intervertebral disc degeneration (IDD) is a complex chronic disease involving nucleus pulposus cells (NPCs) senescence, apoptosis, autophagy and extracellular matrix (ECM) degradation. In this study, we aimed to investigate the role of human adipose tissue stem cells (hASCs)-derived exos...

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Detalles Bibliográficos
Autores principales: Chen, Dong, Jiang, Xin, Zou, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025964/
https://www.ncbi.nlm.nih.gov/pubmed/36950198
http://dx.doi.org/10.1016/j.jot.2023.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025964/
https://www.ncbi.nlm.nih.gov/pubmed/36950198
http://dx.doi.org/10.1016/j.jot.2023.02.004

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