Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene

DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses, mostly when present in cells in a non-replicative state with low copy numbers. However, the sheer amount of viral DNA produced within a very shor...

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Detalles Bibliográficos
Autores principales: Didara, Zrinka, Reithofer, Florian, Zöttl, Karina, Jürets, Alexander, Kiss, Izabella, Witte, Angela, Klein, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025986/
https://www.ncbi.nlm.nih.gov/pubmed/36950281
http://dx.doi.org/10.1016/j.omtn.2023.02.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025986/
https://www.ncbi.nlm.nih.gov/pubmed/36950281
http://dx.doi.org/10.1016/j.omtn.2023.02.033

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