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Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene
DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses, mostly when present in cells in a non-replicative state with low copy numbers. However, the sheer amount of viral DNA produced within a very shor...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025986/ https://www.ncbi.nlm.nih.gov/pubmed/36950281 http://dx.doi.org/10.1016/j.omtn.2023.02.033 |