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Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice

In mature bone, NGF is produced by osteoblasts following mechanical loading and signals through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), to support bone formation. Here, we investigated whether osteoblastic expression of Toll...

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Detalles Bibliográficos
Autores principales: Rajpar, Ibtesam, Kumar, Gaurav, Fortina, Paolo, Tomlinson, Ryan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025993/
https://www.ncbi.nlm.nih.gov/pubmed/36950122
http://dx.doi.org/10.1016/j.isci.2023.106304