The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential physiological metabolite from the mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-infla...

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Detalles Bibliográficos
Autores principales: Liu, Liang, Zhang, Wanying, Liu, Tanghao, Tan, Yangfan, Chen, Cheng, Zhao, Jun, Geng, Huan, Ma, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026041/
https://www.ncbi.nlm.nih.gov/pubmed/36924682
http://dx.doi.org/10.1016/j.redox.2023.102663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026041/
https://www.ncbi.nlm.nih.gov/pubmed/36924682
http://dx.doi.org/10.1016/j.redox.2023.102663

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