Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning

Chimeric antigen receptor (CAR) costimulatory domains derived from native immune receptors steer the phenotypic output of therapeutic T cells. We constructed a library of CARs containing ~2,300 synthetic costimulatory domains, built from combinations of 13 signaling motifs. These CARs promoted diver...

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Detalles Bibliográficos
Autores principales: Daniels, Kyle G., Wang, Shangying, Simic, Milos S., Bhargava, Hersh K., Capponi, Sara, Tonai, Yurie, Yu, Wei, Bianco, Simone, Lim, Wendell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026561/
https://www.ncbi.nlm.nih.gov/pubmed/36480602
http://dx.doi.org/10.1126/science.abq0225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026561/
https://www.ncbi.nlm.nih.gov/pubmed/36480602
http://dx.doi.org/10.1126/science.abq0225

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