Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In this study, we designed 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2 TK inhibitors. We...

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Detalles Bibliográficos
Autores principales: Hassan, Abdelfattah, Mubarak, Fawzy A. F., Shehadi, Ihsan A., Mosallam, Ahmed M., Temairk, Hussain, Badr, Mohamed, Abdelmonsef, Aboubakr H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026756/
https://www.ncbi.nlm.nih.gov/pubmed/36919632
http://dx.doi.org/10.1080/14756366.2023.2189578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026756/
https://www.ncbi.nlm.nih.gov/pubmed/36919632
http://dx.doi.org/10.1080/14756366.2023.2189578

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