Cargando…

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular modeling simulations

Recently, scientists developed a powerful strategy called “one drug-multiple targets” to discover vital and unique therapies to fight the most challenging diseases. Novel derivatives of isatin-based Schiff bases 2–7 have been synthesized by the reaction of 3-hydrazino-isatin (1) with aryl aldehydes,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassan, Ashraf S., Morsy, Nesrin M., Aboulthana, Wael M., Ragab, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026821/ https://www.ncbi.nlm.nih.gov/pubmed/36950709 http://dx.doi.org/10.1039/d3ra00297g

Ejemplares similares

In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic
por: Alkahtani, Hamad M., et al.
Publicado: (2023)

Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives
por: Chinnasamy, Rajaram Prakash, et al.
Publicado: (2010)

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
por: Aboul-Fadl, Tarek, et al.
Publicado: (2012)

Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff Base
por: Hassan, Ali M., et al.
Publicado: (2022)

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
por: Mansour, Mostafa A., et al.
Publicado: (2020)

Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases
por: Mesripour, Azadeh, et al.
Publicado: (2023)

Synthesis and Evaluation of 1,3 Di-Substituted Schiff, Mannich Bases and Spiro Isatin Derivatives
por: Mondal, P, et al.
Publicado: (2010)

Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide
por: Abdulghani, Ahlam J., et al.
Publicado: (2011)

Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
por: Bulatov, Emil, et al.
Publicado: (2018)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

434 In silico ADMET optimization and preliminary biologic activity of novel spermine oxidase inhibitors as neuroprotective agents
por: Furbish, Amelia B, et al.
Publicado: (2022)

Synthesis, characterization, computational analyses, in silico ADMET studies, and inhibitory action against SARS-CoV-2 main protease (Mpro) of a Schiff base
por: ŞAHİN, Songül, et al.
Publicado: (2022)

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles
por: Hassan, Ashraf S., et al.
Publicado: (2019)

Isatin Schiff base is an effective corrosion inhibitor for mild steel in hydrochloric acid solution: gravimetrical, electrochemical, and computational investigation
por: Al-Amiery, Ahmed A., et al.
Publicado: (2022)

Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
por: Durgun, Mustafa, et al.
Publicado: (2020)

In silico ADMET, molecular docking and molecular simulation-based study of glabridin’s natural and semisynthetic derivatives as potential tyrosinase inhibitors
por: Kumari, Arti, et al.
Publicado: (2022)

An in silico evaluation of the ADMET profile of the StreptomeDB database
por: Ntie-Kang, Fidele
Publicado: (2013)

FP-ADMET: a compendium of fingerprint-based ADMET prediction models
por: Venkatraman, Vishwesh
Publicado: (2021)

Docking study, molecular dynamic, synthesis, anti-α-glucosidase assessment, and ADMET prediction of new benzimidazole-Schiff base derivatives
por: Azizian, Homa, et al.
Publicado: (2022)

Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents
por: Kotb, Anas Ramadan, et al.
Publicado: (2023)

Bis benzothiophene Schiff bases: synthesis and in silico-guided biological activity studies
por: ÜNVER, Yasemin, et al.
Publicado: (2020)

Novel Bromo and methoxy substituted Schiff base complexes of Mn(II), Fe(III), and Cr(III) for anticancer, antimicrobial, docking, and ADMET studies
por: Abdel-Rahman, Laila H., et al.
Publicado: (2023)

Copper(II) Chelates of Schiff Bases Enriched with Aliphatic Fragments: Synthesis, Crystal Structure, In Silico Studies of ADMET Properties and a Potency against a Series of SARS-CoV-2 Proteins
por: Panova, Elizaveta V., et al.
Publicado: (2023)

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity
por: Hassan, Ashraf S., et al.
Publicado: (2020)

A novel cerium(iii)–isatin Schiff base complex: spectrofluorometric and DFT studies and application as a kidney biomarker for ultrasensitive detection of human creatinine
por: Sheta, Sheta M., et al.
Publicado: (2020)

Cobalt isatin-Schiff-base derivative of MOF as a heterogeneous multifunctional bio-photocatalyst for sunlight-induced tandem air oxidation condensation process
por: Rouzifar, Majid, et al.
Publicado: (2023)

Synthesis, Biological Activity and Preliminary in Silico ADMET Screening of Polyamine Conjugates with Bicyclic Systems
por: Szumilak, Marta, et al.
Publicado: (2017)

Antibacterial, Anticandidal, and Antibiofilm Potential of Fenchone: In Vitro, Molecular Docking and In Silico/ADMET Study
por: Ahmad, Wasim, et al.
Publicado: (2022)

Potential inhibitory activity of phytoconstituents against black fungus: In silico ADMET, molecular docking and MD simulation studies
por: Hamaamin Hussen, Narmin, et al.
Publicado: (2022)

In silico screening, ADMET analysis and MD simulations of phytochemicals of Onosma bracteata Wall. as SARS CoV-2 inhibitors
por: Vegad, Udaykumar G., et al.
Publicado: (2023)

In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases
por: Almalki, Faisal A., et al.
Publicado: (2021)

ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database
por: Dong, Jie, et al.
Publicado: (2018)

New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges
por: Naglah, Ahmed M., et al.
Publicado: (2016)

Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones
por: Bekircan, Olcay, et al.
Publicado: (2008)

Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates
por: Ibrahim, Musab Mohamed, et al.
Publicado: (2018)

Synthesis and synergistic studies of isatin based mixed ligand complexes as potential antifungal therapeutic agents
por: Dar, Ovas Ahmad, et al.
Publicado: (2019)

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies
por: Dhiman, Priyanka, et al.
Publicado: (2020)

Isatin derivatives as broad-spectrum antiviral agents: the current landscape
por: Elsaman, Tilal, et al.
Publicado: (2022)

N-Benzylisatin
por: Schutte, M., et al.
Publicado: (2012)

Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents
por: Rashdan, Huda R. M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g7132dlngmdekil70mhssk927m