Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4(+) T cells are ubiquitous but decrease with age. We id...

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Detalles Bibliográficos
Autores principales: Loyal, Lucie, Braun, Julian, Henze, Larissa, Kruse, Beate, Dingeldey, Manuela, Reimer, Ulf, Kern, Florian, Schwarz, Tatjana, Mangold, Maike, Unger, Clara, Dörfler, Friederike, Kadler, Shirin, Rosowski, Jennifer, Gürcan, Kübrah, Uyar-Aydin, Zehra, Frentsch, Marco, Kurth, Florian, Schnatbaum, Karsten, Eckey, Maren, Hippenstiel, Stefan, Hocke, Andreas, Müller, Marcel A., Sawitzki, Birgit, Miltenyi, Stefan, Paul, Friedemann, Mall, Marcus A., Wenschuh, Holger, Voigt, Sebastian, Drosten, Christian, Lauster, Roland, Lachman, Nils, Sander, Leif-Erik, Corman, Victor M., Röhmel, Jobst, Meyer-Arndt, Lil, Thiel, Andreas, Giesecke-Thiel, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026850/
https://www.ncbi.nlm.nih.gov/pubmed/34465633
http://dx.doi.org/10.1126/science.abh1823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026850/
https://www.ncbi.nlm.nih.gov/pubmed/34465633
http://dx.doi.org/10.1126/science.abh1823

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