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Structure-based design of oligomeric receptor-binding domain (RBD) recombinant proteins as potent vaccine candidates against SARS-CoV-2

The receptor-binding domain (RBD) of SARS-CoV-2 S protein is proved to be the major target of neutralizing antibodies. However, on the S protein, only a portion of epitopes in RBD can be effectively displayed with dynamic changes in spatial conformations. Using RBD fragment as antigen can better exp...

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Detalles Bibliográficos
Autores principales:	Zhang, Ting, Zheng, Ningchen, Wang, Zhirong, Xu, Xuemei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Coronavirus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026890/ https://www.ncbi.nlm.nih.gov/pubmed/36846890 http://dx.doi.org/10.1080/21645515.2023.2174755

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