11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Ang...

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Detalles Bibliográficos
Autores principales: Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027213/
https://www.ncbi.nlm.nih.gov/pubmed/36940215
http://dx.doi.org/10.1371/journal.pone.0255709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027213/
https://www.ncbi.nlm.nih.gov/pubmed/36940215
http://dx.doi.org/10.1371/journal.pone.0255709

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