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An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition
The main protease from SARS-CoV-2 (M(pro)) is responsible for cleavage of the viral polyprotein. M(pro) self-processing is called maturation, and it is crucial for enzyme dimerization and activity. Here we use C145S M(pro) to study the structure and dynamics of N-terminal cleavage in solution. Nativ...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027274/ https://www.ncbi.nlm.nih.gov/pubmed/36941262 http://dx.doi.org/10.1038/s41467-023-37035-5 |