An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

The main protease from SARS-CoV-2 (M(pro)) is responsible for cleavage of the viral polyprotein. M(pro) self-processing is called maturation, and it is crucial for enzyme dimerization and activity. Here we use C145S M(pro) to study the structure and dynamics of N-terminal cleavage in solution. Nativ...

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Detalles Bibliográficos
Autores principales: Noske, Gabriela Dias, Song, Yun, Fernandes, Rafaela Sachetto, Chalk, Rod, Elmassoudi, Haitem, Koekemoer, Lizbé, Owen, C. David, El-Baba, Tarick J., Robinson, Carol V., Oliva, Glaucius, Godoy, Andre Schutzer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027274/
https://www.ncbi.nlm.nih.gov/pubmed/36941262
http://dx.doi.org/10.1038/s41467-023-37035-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027274/
https://www.ncbi.nlm.nih.gov/pubmed/36941262
http://dx.doi.org/10.1038/s41467-023-37035-5

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