Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation. Several TCA cycle components are implicated in tumorigenesis, including loss-of-function mu...

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Detalles Bibliográficos
Autores principales: Hart, Madeleine L, Quon, Evan, Vigil, Anna-Lena BG, Engstrom, Ian A, Newsom, Oliver J, Davidsen, Kristian, Hoellerbauer, Pia, Carlisle, Samantha M, Sullivan, Lucas B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027318/
https://www.ncbi.nlm.nih.gov/pubmed/36883551
http://dx.doi.org/10.7554/eLife.78654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027318/
https://www.ncbi.nlm.nih.gov/pubmed/36883551
http://dx.doi.org/10.7554/eLife.78654

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