Cargando…

Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation. Several TCA cycle components are implicated in tumorigenesis, including loss-of-function mu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hart, Madeleine L, Quon, Evan, Vigil, Anna-Lena BG, Engstrom, Ian A, Newsom, Oliver J, Davidsen, Kristian, Hoellerbauer, Pia, Carlisle, Samantha M, Sullivan, Lucas B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027318/ https://www.ncbi.nlm.nih.gov/pubmed/36883551 http://dx.doi.org/10.7554/eLife.78654

Ejemplares similares

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
por: Cardaci, Simone, et al.
Publicado: (2015)

A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging
por: Yang, Xingbo, et al.
Publicado: (2021)

Mechano-redox control of integrin de-adhesion
por: Passam, Freda, et al.
Publicado: (2018)

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
por: Phillips, Charles B, et al.
Publicado: (2019)

Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress
por: Crawford, Robert A, et al.
Publicado: (2022)

An engineered biosensor enables dynamic aspartate measurements in living cells
por: Davidsen, Kristian, et al.
Publicado: (2023)

Temporal profiling of redox-dependent heterogeneity in single cells
por: Radzinski, Meytal, et al.
Publicado: (2018)

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase
por: Wittenborn, Elizabeth C, et al.
Publicado: (2018)

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis
por: Pal, Virender Kumar, et al.
Publicado: (2021)

Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life
por: Méheust, Raphaël, et al.
Publicado: (2021)

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
por: Ryan, Dylan Gerard, et al.
Publicado: (2021)

NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus
por: Wible, Ryan S, et al.
Publicado: (2018)

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production
por: Bongers, Mareike, et al.
Publicado: (2020)

A helicase-tethered ORC flip enables bidirectional helicase loading
por: Gupta, Shalini, et al.
Publicado: (2021)

Peroxiredoxin promotes longevity and H(2)O(2)-resistance in yeast through redox-modulation of protein kinase A
por: Roger, Friederike, et al.
Publicado: (2020)

Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
por: Samandi, Sondos, et al.
Publicado: (2017)

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity
por: Shaaya, Mark, et al.
Publicado: (2020)

AKAP79 enables calcineurin to directly suppress protein kinase A activity
por: Church, Timothy W, et al.
Publicado: (2021)

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds
por: Entova, Sonya, et al.
Publicado: (2018)

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications
por: Ayoubi, Riham, et al.
Publicado: (2023)

Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control
por: Wu, Meiling, et al.
Publicado: (2022)

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography
por: John, Juliane, et al.
Publicado: (2022)

Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics
por: Keyes, Jeremiah, et al.
Publicado: (2020)

A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
por: Maini Rekdal, Vayu, et al.
Publicado: (2020)

N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
por: Okuma, Hidehiko, et al.
Publicado: (2023)

Cross-talk between individual phenol-soluble modulins in Staphylococcus aureus biofilm enables rapid and efficient amyloid formation
por: Zaman, Masihuz, et al.
Publicado: (2020)

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells
por: Kirkemo, Lisa L, et al.
Publicado: (2022)

Optical estimation of absolute membrane potential using fluorescence lifetime imaging
por: Lazzari-Dean, Julia R, et al.
Publicado: (2019)

Ribozyme activity modulates the physical properties of RNA–peptide coacervates
por: Le Vay, Kristian Kyle, et al.
Publicado: (2023)

Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination
por: Singh, Raushan K, et al.
Publicado: (2021)

Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence
por: Sun, Wei-Sheng, et al.
Publicado: (2023)

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
por: Paxman, Ryan, et al.
Publicado: (2018)

The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand
por: Zuber, Philipp K, et al.
Publicado: (2018)

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo
por: Willimsky, Gerald, et al.
Publicado: (2021)

Structure of the connexin-43 gap junction channel in a putative closed state
por: Qi, Chao, et al.
Publicado: (2023)

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
por: Kroef, Virginia, et al.
Publicado: (2022)

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
por: Sullivan, Mark R, et al.
Publicado: (2019)

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
por: Karandur, Deepti, et al.
Publicado: (2020)

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
por: Avet, Charlotte, et al.
Publicado: (2022)

Radio digital SDH/
por: Castellanos Moreno, Fabiola Melina
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_hiane326k4mipmtkmj9hk2e9in