Pembrolizumab for the treatment of disease relapse after allogeneic hematopoietic stem cell transplantation

A failed graft-versus-tumor (GVT) effect is a common mechanism of relapse after allogeneic hematopoietic cell transplantation (alloHCT). Although targeting the PD-1/PD-L1 axis may restore GVT effects, PD-1 blockade exacerbates graft-versus-host disease (GVHD) in murine models, and severe GVHD can oc...

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Detalles Bibliográficos
Autores principales: Godfrey, James, Liu, Hongtao, Yu, Jovian, Tallarico, Michael, Curran, Emily, Artz, Andrew, Riedell, Peter A., Stock, Wendy, Karrison, Theodore, Fitzpatrick, Carrie, Venkataraman, Girish, Cooper, Alan, Smith, Sonali M., Bishop, Michael R., Kline, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027501/
https://www.ncbi.nlm.nih.gov/pubmed/35973200
http://dx.doi.org/10.1182/bloodadvances.2022008403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027501/
https://www.ncbi.nlm.nih.gov/pubmed/35973200
http://dx.doi.org/10.1182/bloodadvances.2022008403

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