Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus

Anti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and antigenic properties. Unexpectedly, during the clinical and molecular characterization of autoantibodies to the endonuclease DNase1L3 in patients with systemic lupus erythematosus (SLE), we identified a subset of n...

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Detalles Bibliográficos
Autores principales: Gomez-Bañuelos, Eduardo, Yu, Yikai, Li, Jessica, Cashman, Kevin S., Paz, Merlin, Trejo-Zambrano, Maria Isabel, Bugrovsky, Regina, Wang, Youliang, Chida, Asiya Seema, Sherman-Baust, Cheryl A., Ferris, Dylan P., Goldman, Daniel W., Darrah, Erika, Petri, Michelle, Sanz, Iñaki, Andrade, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027674/
https://www.ncbi.nlm.nih.gov/pubmed/36941260
http://dx.doi.org/10.1038/s41467-023-37083-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027674/
https://www.ncbi.nlm.nih.gov/pubmed/36941260
http://dx.doi.org/10.1038/s41467-023-37083-x

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