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Frozen fresh blood plasma preserves the functionality of native human α(2)-macroglobulin

Human α(2)-macroglobulin (hα(2)M) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. Following cleavage within a bait region, hα(2)M undergoes stepwise transitions from its native, expanded, highly flexible, active conformation to an induced, compact, triggered con...

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Detalles Bibliográficos
Autores principales: Mendes, Soraia R., Gomis-Rüth, F. Xavier, Goulas, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027685/
https://www.ncbi.nlm.nih.gov/pubmed/36941303
http://dx.doi.org/10.1038/s41598-023-31800-8