Cargando…

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment

BACKGROUND: Previous studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process of efferocytosis is a major contributor to the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cruz Cruz, Joselyn, Allison, Kristen C., Page, Lauren S., Jenkins, Alexis J., Wang, Xiaodong, Earp, H. Shelton, Frye, Stephen V., Graham, Douglas K., Verneris, Michael R., Lee-Sherick, Alisa B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027704/ https://www.ncbi.nlm.nih.gov/pubmed/36960055 http://dx.doi.org/10.3389/fimmu.2023.1146721

Ejemplares similares

MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity
por: Lee-Sherick, Alisa B., et al.
Publicado: (2020)

Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Tumor Microenvironment
por: Koo, Jane, et al.
Publicado: (2020)

Efferocytosis in the tumor microenvironment
por: Werfel, Thomas A., et al.
Publicado: (2018)

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia
por: Lee-Sherick, Alisa B., et al.
Publicado: (2015)

Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation
por: Sandahl, Melissa, et al.
Publicado: (2010)

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
por: Sufit, Alexandra, et al.
Publicado: (2016)

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
por: Birge, R B, et al.
Publicado: (2016)

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment
por: Chen, Wuzhen, et al.
Publicado: (2021)

Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes
por: Schrodt, Michael V., et al.
Publicado: (2023)

New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs
por: Lakshmanachetty, Senthilnath, et al.
Publicado: (2021)

Efferocytosis and autoimmune disease
por: Kawano, Mahiru, et al.
Publicado: (2018)

Efferocytosis in multisystem diseases
por: Zhang, Yifan, et al.
Publicado: (2022)

Efferocytosis and Respiratory Disease
por: Zheng, Wenxue, et al.
Publicado: (2023)

Targeting the TAM Receptors in Leukemia
por: Huey, Madeline G., et al.
Publicado: (2016)

Sonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes
por: Wang, Dingyi, et al.
Publicado: (2022)

Modulation of Macrophage Efferocytosis in Inflammation
por: Korns, Darlynn, et al.
Publicado: (2011)

The Role of Efferocytosis in Autoimmune Diseases
por: Abdolmaleki, Fereshte, et al.
Publicado: (2018)

Efferocytosis of Pathogen-Infected Cells
por: Karaji, Niloofar, et al.
Publicado: (2017)

Efferocytosis is impaired in Gaucher macrophages
por: Aflaki, Elma, et al.
Publicado: (2017)

Efferocytosis in the Central Nervous System
por: Zhao, Jiayi, et al.
Publicado: (2021)

Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells
por: Qi, Fei-long, et al.
Publicado: (2020)

Oncolytic virotherapy reverses the immunosuppressive tumor microenvironment and its potential in combination with immunotherapy
por: Zhang, Yalei, et al.
Publicado: (2021)

Immunosuppressive Microenvironment in Neuroblastoma
por: Pistoia, Vito, et al.
Publicado: (2013)

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment
por: Kaweme, Natasha Mupeta, et al.
Publicado: (2021)

Efferocytosis in oral squamous cell carcinoma
por: Sarode, Gargi S
Publicado: (2016)

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
por: Yurdagul, Arif, et al.
Publicado: (2018)

Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
por: Wang, Lili, et al.
Publicado: (2021)

Efferocytosis and Anthrax: Implications for Bacterial Sepsis?
por: Mytych, Joshua S., et al.
Publicado: (2021)

Efferocytosis during Skeletal Muscle Regeneration
por: Juban, Gaëtan, et al.
Publicado: (2021)

Cellular Responses to the Efferocytosis of Apoptotic Cells
por: Yin, Charles, et al.
Publicado: (2021)

Efferocytosis and Its Role in Inflammatory Disorders
por: Ge, Yun, et al.
Publicado: (2022)

Importance of Efferocytosis in COVID-19 Mortality
por: Erol, Adnan
Publicado: (2022)

Drugging the efferocytosis process: concepts and opportunities
por: Mehrotra, Parul, et al.
Publicado: (2022)

Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia
por: Summers, Ryan J., et al.
Publicado: (2022)

Immunosuppression-associated posterior reversible encephalopathy syndrome in an acute leukemia case
por: Malkan, Umit Y., et al.
Publicado: (2018)

Promoter Specificity and Efficacy in Conditional and Inducible Transgenic Targeting of Lung Macrophages
por: McCubbrey, Alexandra L., et al.
Publicado: (2017)

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages
por: Zarrow, Jonah E., et al.
Publicado: (2023)

CD200 promotes immunosuppression in the pancreatic tumor microenvironment
por: Choueiry, Fouad, et al.
Publicado: (2020)

Modes of immunosuppression in glioblastoma microenvironment
por: Lehtipuro, Suvi, et al.
Publicado: (2019)

Role of the immunosuppressive microenvironment in immunotherapy
por: Tormoen, Garth W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_22ongk34qppc6lf6k8kkicsr5k