Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes

Obesity is one of the most prevalent chronic metabolic diseases, and induction of apoptosis in preadipocytes and adipocytes is a potential strategy to treat obesity. Celastrol represents one of the most robust anti-obesity phytochemicals so far, yet its direct binding target remains elusive. Here, w...

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Detalles Bibliográficos
Autores principales: Liu, Chenshu, Li, Na, Peng, Meixiu, Huang, Kan, Fan, Dongxiao, Zhao, Zhengde, Huang, Xiuyi, Liu, Yunchong, Chen, Sifan, Li, Zilun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027750/
https://www.ncbi.nlm.nih.gov/pubmed/36959859
http://dx.doi.org/10.3389/fphar.2023.1094584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027750/
https://www.ncbi.nlm.nih.gov/pubmed/36959859
http://dx.doi.org/10.3389/fphar.2023.1094584

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