Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Roseocin, the two-peptide lantibiotic from Streptomyces roseosporus, carries extensive intramolecular (methyl)lanthionine bridging in the peptides and exhibits synergistic antibacterial activity against clinically relevant Gram-positive pathogens. Both peptides have a conserved leader but a diverse...

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Detalles Bibliográficos
Autores principales: Chaudhary, Sandeep, Kishen, Shweta, Singh, Mangal, Jassal, Sunanda, Pathania, Reeva, Bisht, Kalpana, Sareen, Dipti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027976/
https://www.ncbi.nlm.nih.gov/pubmed/36940043
http://dx.doi.org/10.1186/s13568-023-01536-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027976/
https://www.ncbi.nlm.nih.gov/pubmed/36940043
http://dx.doi.org/10.1186/s13568-023-01536-9

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