Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma

BACKGROUND: Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging. We previously reported that KR12, a DNA‐alkylating pyrrole‐imidazole polyamide designed to re...

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Detalles Bibliográficos
Autores principales: Tsujimoto, Akiko, Matsuo, Niina, Lai, Xiaoyi, Inoue, Takahiro, Yoda, Hiroyuki, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028039/
https://www.ncbi.nlm.nih.gov/pubmed/36262061
http://dx.doi.org/10.1002/cam4.5359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028039/
https://www.ncbi.nlm.nih.gov/pubmed/36262061
http://dx.doi.org/10.1002/cam4.5359

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