Pseudoknot-targeting Cas13b combats SARS-CoV-2 infection by suppressing viral replication

CRISPR-Cas13-mediated viral genome targeting is a novel strategy for defending against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Here, we generated mRNA-encoded Cas13b targeting the open reading frame 1b (ORF1b) region to effectively degrade the RNA-dependent RNA polymer...

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Detalles Bibliográficos
Autores principales: Yu, Daseuli, Han, Hee-Jeong, Yu, Jeonghye, Kim, Jihye, Lee, Gun-Hee, Yang, Ju-Hee, Song, Byeong-Min, Tark, Dongseob, Choi, Byeong-Sun, Kang, Sang-Min, Heo, Won Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028249/
https://www.ncbi.nlm.nih.gov/pubmed/36945774
http://dx.doi.org/10.1016/j.ymthe.2023.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028249/
https://www.ncbi.nlm.nih.gov/pubmed/36945774
http://dx.doi.org/10.1016/j.ymthe.2023.03.018

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