The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing

The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines agai...

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Detalles Bibliográficos
Autores principales: Bian, Zhongzheng, Wu, Ziqian, Liu, Nan, Jiang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Microbial Genetics • Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028319/
https://www.ncbi.nlm.nih.gov/pubmed/36943642
http://dx.doi.org/10.1007/s13353-023-00756-w
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author Bian, Zhongzheng
Wu, Ziqian
Liu, Nan
Jiang, Xiao
author_facet Bian, Zhongzheng
Wu, Ziqian
Liu, Nan
Jiang, Xiao
author_sort Bian, Zhongzheng
collection PubMed
description The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines.
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spelling pubmed-100283192023-03-21 The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing Bian, Zhongzheng Wu, Ziqian Liu, Nan Jiang, Xiao J Appl Genet Microbial Genetics • Original Paper The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines. Springer Berlin Heidelberg 2023-03-21 2023 /pmc/articles/PMC10028319/ /pubmed/36943642 http://dx.doi.org/10.1007/s13353-023-00756-w Text en © The Author(s), under exclusive licence to Institute of Plant Genetics Polish Academy of Sciences 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Microbial Genetics • Original Paper
Bian, Zhongzheng
Wu, Ziqian
Liu, Nan
Jiang, Xiao
The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title_full The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title_fullStr The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title_full_unstemmed The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title_short The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing
title_sort efficacy and safety of sars-cov-2 vaccines mrna1273 and bnt162b2 might be complicated by rampant c-to-u rna editing
topic Microbial Genetics • Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028319/
https://www.ncbi.nlm.nih.gov/pubmed/36943642
http://dx.doi.org/10.1007/s13353-023-00756-w
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