Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

Central metabolic pathways controls virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose phosphate pathway (PPP) remains largely unexplored. Mutation of the 6-phosphogluconolactonase gene pgl, which encodes th...

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Detalles Bibliográficos
Autores principales: Zeden, Merve S., Gallagher, Laura A., Bueno, Emilio, Nolan, Aaron C., Ahn, Jongsam, Shinde, Dhananjay, Razvi, Fareha, Sladek, Margaret, Burke, Órla, O’Neill, Eoghan, Fey, Paul D., Cava, Felipe, Thomas, Vinai C., O’Gara, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028837/
https://www.ncbi.nlm.nih.gov/pubmed/36945400
http://dx.doi.org/10.1101/2023.03.03.530734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028837/
https://www.ncbi.nlm.nih.gov/pubmed/36945400
http://dx.doi.org/10.1101/2023.03.03.530734

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