Cargando…

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

Central metabolic pathways controls virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose phosphate pathway (PPP) remains largely unexplored. Mutation of the 6-phosphogluconolactonase gene pgl, which encodes th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeden, Merve S., Gallagher, Laura A., Bueno, Emilio, Nolan, Aaron C., Ahn, Jongsam, Shinde, Dhananjay, Razvi, Fareha, Sladek, Margaret, Burke, Órla, O’Neill, Eoghan, Fey, Paul D., Cava, Felipe, Thomas, Vinai C., O’Gara, James P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028837/ https://www.ncbi.nlm.nih.gov/pubmed/36945400 http://dx.doi.org/10.1101/2023.03.03.530734

Ejemplares similares

Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
por: Zeden, Merve S., et al.
Publicado: (2023)

Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics
por: Campbell, Christopher, et al.
Publicado: (2021)

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics
por: Nolan, Aaron C., et al.
Publicado: (2022)

Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth of Staphylococcus aureus in Defined Medium Lacking Glucose and Arginine
por: Reslane, Itidal, et al.
Publicado: (2022)

Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus
por: Zeden, Merve Suzan, et al.
Publicado: (2021)

Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c‐di‐AMP production
por: Zeden, Merve S., et al.
Publicado: (2020)

Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation
por: Zapotoczna, Marta, et al.
Publicado: (2016)

Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
por: McCarthy, Hannah, et al.
Publicado: (2015)

Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration
por: Chaudhari, Sujata S., et al.
Publicado: (2017)

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA
por: Gonzales, Patrick R., et al.
Publicado: (2015)

Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae
por: Bueno, Emilio, et al.
Publicado: (2022)

Proline transporters ProT and PutP are required for Staphylococcus aureus infection
por: Lehman, McKenzie K., et al.
Publicado: (2023)

A critical role for staphylococcal nitric oxide synthase in controlling flavohemoglobin toxicity
por: Singh, Ryan M., et al.
Publicado: (2023)

Marine Pseudovibrio sp. as a Novel Source of Antimicrobials
por: Crowley, Susan P., et al.
Publicado: (2014)

Pentose Metabolism in Bacteria
por: Rose, Irwin A.
Publicado: (1963)

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams
por: Farha, Maya A., et al.
Publicado: (2012)

The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response
por: Kim, Choonkeun, et al.
Publicado: (2013)

1066. Adjuvant β-Lactam Therapy Combined with Vancomycin for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: Does β-Lactam class Matter?
por: Dilworth, Thomas J, et al.
Publicado: (2018)

Complete Genome Sequence of Staphylococcus epidermidis CSF41498
por: Galac, M. R., et al.
Publicado: (2019)

Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)
por: Blázquez, Blas, et al.
Publicado: (2014)

Correction: The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response
por: Kim, Choonkeun, et al.
Publicado: (2014)

Molecular Determinants of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA): An Updated Review
por: Lade, Harshad, et al.
Publicado: (2023)

The Pentose Phosphate Pathway Regulates the Circadian Clock
por: Rey, Guillaume, et al.
Publicado: (2016)

The SPI-1-like Type III secretion system: more roles than you think
por: Egan, Frank, et al.
Publicado: (2014)

Addiction psychiatry and COVID-19: impact on patients and service provision
por: Columb, D., et al.
Publicado: (2020)

Impact of Bicarbonate-β-Lactam Exposures on Methicillin-Resistant Staphylococcus aureus (MRSA) Gene Expression in Bicarbonate-β-Lactam-Responsive vs. Non-Responsive Strains
por: Ersoy, Selvi C., et al.
Publicado: (2021)

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus
por: Zapotoczna, Marta, et al.
Publicado: (2017)

Molecular docking and proteomics reveals the synergistic antibacterial mechanism of theaflavin with β-lactam antibiotics against MRSA
por: Guan, Shuhan, et al.
Publicado: (2022)

Heated Air Delivery by Micro-Sauna: An Experimental Treatment Prototype Concept for Coronavirus Disease 2019
por: Knio, Ziyad O, et al.
Publicado: (2020)

β-Lactam Resistance and Enterobacteriaceae, United States
por: Whichard, Jean M., et al.
Publicado: (2005)

Tobacco industry misappropriation of American Indian culture and traditional tobacco
por: D’Silva, Joanne, et al.
Publicado: (2018)

Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic Pathogen Pseudomonas aeruginosa
por: Flynn, Stephanie, et al.
Publicado: (2019)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

Functionalization of β-lactam antibiotic on lysozyme capped gold nanoclusters retrogress MRSA and its persisters following awakening
por: Kalita, Sanjeeb, et al.
Publicado: (2018)

Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains
por: Kwiatkowski, Paweł, et al.
Publicado: (2020)

Microbiome and Functional Analysis of a Traditional Food Process: Isolation of a Novel Species (Vibrio hibernica) With Industrial Potential
por: Woods, David F., et al.
Publicado: (2020)

Abstract 32 Low Incidence of Product Complaints and Adverse Events Support Safety of Cord Blood Units
por: O’Gara, Erin, et al.
Publicado: (2022)

Thermosensitive PBP2a requires extracellular folding factors PrsA and HtrA1 for Staphylococcus aureus MRSA β-lactam resistance
por: Roch, Mélanie, et al.
Publicado: (2019)

A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress
por: Chittezham Thomas, Vinai, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0jgjk5dsbtdq74nvgo9q5fb8ti