Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout aging

Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here, we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evolution of the mt-genome in different tissues throughout agin...

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Detalles Bibliográficos
Autores principales: Serrano, Isabel M., Hirose, Misa, Valentine, Charles C., Roesner, Sharon, Schmidt, Elizabeth, Pratt, Gabriel, Williams, Lindsey, Salk, Jesse, Ibrahim, Saleh, Sudmant, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028854/
https://www.ncbi.nlm.nih.gov/pubmed/36945529
http://dx.doi.org/10.1101/2023.03.06.531392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028854/
https://www.ncbi.nlm.nih.gov/pubmed/36945529
http://dx.doi.org/10.1101/2023.03.06.531392

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