Cargando…
Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout aging
Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here, we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evolution of the mt-genome in different tissues throughout agin...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028854/ https://www.ncbi.nlm.nih.gov/pubmed/36945529 http://dx.doi.org/10.1101/2023.03.06.531392 |