Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Influenza virus activates cellular inflammasome pathways, which can be either beneficial or detrimental to infection outcomes. Here, we investigated the role of the inflammasome-activated pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice significantly...

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Detalles Bibliográficos
Autores principales: Speaks, Samuel, Zani, Ashley, Solstad, Abigail, Kenney, Adam, McFadden, Matthew I., Zhang, Lizhi, Eddy, Adrian C., Amer, Amal O., Robinson, Richard, Cai, Chuanxi, Ma, Jianjie, Hemann, Emily A., Forero, Adriana, Yount, Jacob S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028878/
https://www.ncbi.nlm.nih.gov/pubmed/36945485
http://dx.doi.org/10.1101/2023.03.08.531787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028878/
https://www.ncbi.nlm.nih.gov/pubmed/36945485
http://dx.doi.org/10.1101/2023.03.08.531787

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