Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to repurpose multiple evolutionarily conserved cellular signaling pathways including Wnt, Notch and Hedgehog. In this investigation, we demonstrate that E. chaffeensis and recombinant TRP120 deactivate Hippo s...

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Detalles Bibliográficos
Autores principales: Byerly, Caitlan D., Patterson, LaNisha L., Pittner, Nicholas A., Solomon, Regina N., Patel, Jignesh G., Rogan, Madison R., McBride, Jere W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028901/
https://www.ncbi.nlm.nih.gov/pubmed/36945589
http://dx.doi.org/10.1101/2023.03.06.531456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028901/
https://www.ncbi.nlm.nih.gov/pubmed/36945589
http://dx.doi.org/10.1101/2023.03.06.531456

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