Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Motor symptoms in Parkinson’s disease (PD) are caused by degeneration of dopamine (DA) neurons of the substantia nigra (SN), while early non-motor symptoms such as anxiety and sleep disturbances are likely mediated by dysfunction of locus coeruleus (LC) norepinephrine (NE) neurons. The LC develops α...

Descripción completa

Detalles Bibliográficos
Autores principales: Iannitelli, Alexa F., Segal, Arielle, Pare, Jean-Francoise, Mulvey, Bernard, Liles, L. Cameron, Sloan, Steven A., McCann, Katharine E., Dougherty, Joseph D., Smith, Yoland, Weinshenker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028911/
https://www.ncbi.nlm.nih.gov/pubmed/36945637
http://dx.doi.org/10.1101/2023.03.07.530845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028911/
https://www.ncbi.nlm.nih.gov/pubmed/36945637
http://dx.doi.org/10.1101/2023.03.07.530845

Ejemplares similares