Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall

BACKGROUND: Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and de novo silencing of genes genome-wide, is known to be controlled by DNA methyltransferases (DNMT) and demeth...

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Detalles Bibliográficos
Autores principales: Signoretti, Christina, Gupte, Sachin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028921/
https://www.ncbi.nlm.nih.gov/pubmed/36945640
http://dx.doi.org/10.1101/2023.03.06.531429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028921/
https://www.ncbi.nlm.nih.gov/pubmed/36945640
http://dx.doi.org/10.1101/2023.03.06.531429

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