Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A

Abnormal dendritic arbors, dendritic spine “dysgenesis” and excitation inhibition imbalance are main traits assumed to underlie impaired cognition and behavioral adaptation in intellectual disability. However, how these modifications actually contribute to functional properties of neuronal networks,...

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Detalles Bibliográficos
Autores principales: Manubens-Gil, Linus, Pons-Espinal, Meritxell, Gener, Thomas, Ballesteros-Yañez, Inmaculada, de Lagrán, María Martínez, Dierssen, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028951/
https://www.ncbi.nlm.nih.gov/pubmed/36945607
http://dx.doi.org/10.1101/2023.03.09.531874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028951/
https://www.ncbi.nlm.nih.gov/pubmed/36945607
http://dx.doi.org/10.1101/2023.03.09.531874

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