From GWAS to signal validation: An approach for estimating genetic effects while preserving genomic context

Validating associations between genotypic and phenotypic variation remains a challenge, despite advancements in association studies. Common approaches for signal validation rely on gene-level perturbations, such as loss-of-function mutations or RNAi, which test the effect of genetic modifications us...

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Detalles Bibliográficos
Autores principales: Wolf, Scott, Abhyankar, Varada, Melo, Diogo, Ayroles, Julien F., Pallares, Luisa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028994/
https://www.ncbi.nlm.nih.gov/pubmed/36945453
http://dx.doi.org/10.1101/2023.03.09.531909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028994/
https://www.ncbi.nlm.nih.gov/pubmed/36945453
http://dx.doi.org/10.1101/2023.03.09.531909

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