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From GWAS to signal validation: An approach for estimating genetic effects while preserving genomic context
Validating associations between genotypic and phenotypic variation remains a challenge, despite advancements in association studies. Common approaches for signal validation rely on gene-level perturbations, such as loss-of-function mutations or RNAi, which test the effect of genetic modifications us...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028994/ https://www.ncbi.nlm.nih.gov/pubmed/36945453 http://dx.doi.org/10.1101/2023.03.09.531909 |