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Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch
The SAM/SAH riboswitch binds S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) with similar affinities. Mg(2+) is generally known to stabilize RNA structures by neutralizing phosphates, but how it contributes to ligand binding and conformational transition is understudied. Here, extensive...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029009/ https://www.ncbi.nlm.nih.gov/pubmed/36945415 http://dx.doi.org/10.1101/2023.03.12.532287 |