Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells

The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfunction and contribute to the pathogenesis of numerous diseases...

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Detalles Bibliográficos
Autores principales: Perea, Valerie, Baron, Kelsey R., Dolina, Vivian, Aviles, Giovanni, Rosarda, Jessica D., Guo, Xiaoyan, Kampmann, Martin, Wiseman, R. Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029010/
https://www.ncbi.nlm.nih.gov/pubmed/36945406
http://dx.doi.org/10.1101/2023.03.11.532186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029010/
https://www.ncbi.nlm.nih.gov/pubmed/36945406
http://dx.doi.org/10.1101/2023.03.11.532186

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