Modeling Alzheimer’s disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegeneration

BACKGROUND: Alzheimer’s disease (AD) is the most prevalent form of neurodegeneration. Despite the well-established link between tau aggregation and clinical progression, the major pathways driven by this protein to intrinsically damage neurons are incompletely understood. METHODS: To model AD-releva...

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Detalles Bibliográficos
Autores principales: Li, Sanming, Roy, Ethan R., Wang, Yanyu, Watkins, Trent, Cao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029119/
https://www.ncbi.nlm.nih.gov/pubmed/36945524
http://dx.doi.org/10.21203/rs.3.rs-2617457/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029119/
https://www.ncbi.nlm.nih.gov/pubmed/36945524
http://dx.doi.org/10.21203/rs.3.rs-2617457/v1

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