Cargando…

An animal-free preclinical drug screening platform based on human precision-cut kidney slices

OBJECTIVE: Renal fibrosis is one of the main pathophysiological processes underlying the progression of chronic kidney disease and kidney allograft failure. In the past decades, overwhelming efforts have been undertaken to find druggable targets for the treatment of renal fibrosis, mainly using cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mutsaers, Henricus A. M., Jensen, Michael Schou, Kresse, Jean-Claude, Tingskov, Stine Julie, Madsen, Mia Gebauer, Nørregaard, Rikke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029185/ https://www.ncbi.nlm.nih.gov/pubmed/36941637 http://dx.doi.org/10.1186/s13104-023-06303-4

Ejemplares similares

Activation of the prostaglandin E(2) EP(2) receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices
por: Jensen, Michael Schou, et al.
Publicado: (2019)

EP(1) receptor antagonism mitigates early and late stage renal fibrosis
por: Kresse, Jean‐Claude, et al.
Publicado: (2022)

Local Inhibition of Indoleamine 2,3-Dioxygenase Mitigates Renal Fibrosis
por: Jensen, Camilla Grønkjær, et al.
Publicado: (2021)

Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis
por: Bigaeva, Emilia, et al.
Publicado: (2020)

P2X(7) accelerate tissue fibrosis via metalloproteinase 8‐dependent macrophage infiltration in a murine model of unilateral ureteral obstruction
por: Therkildsen, Jacob Rudjord, et al.
Publicado: (2023)

A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
por: Prins, Grietje H., et al.
Publicado: (2019)

Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs
por: Iswandana, Raditya, et al.
Publicado: (2020)

Transcutaneous measurement of renal function in two rodent models of obstructive nephropathy
por: Jensen, Michael Schou, et al.
Publicado: (2023)

Prostaglandin E2 receptors as therapeutic targets in renal fibrosis
por: Mutsaers, Henricus A.M., et al.
Publicado: (2022)

Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis
por: Stribos, Elisabeth G. D., et al.
Publicado: (2017)

Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets
por: Mutsaers, Henricus A. M., et al.
Publicado: (2021)

Patient-derived precision cut tissue slices from primary liver cancer as a potential platform for preclinical drug testing
por: Jagatia, Ravi, et al.
Publicado: (2023)

Tamoxifen Decreases Lithium-Induced Natriuresis in Rats With Nephrogenic Diabetes Insipidus
por: Tingskov, Stine Julie, et al.
Publicado: (2018)

Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration
por: Nørgård, Mikkel Ø., et al.
Publicado: (2020)

The impact of fibrotic diseases on global mortality from 1990 to 2019
por: Mutsaers, Henricus A. M., et al.
Publicado: (2023)

Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
por: Nørregaard, Rikke, et al.
Publicado: (2023)

Assessment of immunotoxicity using precision-cut tissue slices
por: Sewald, Katherina, et al.
Publicado: (2013)

Generation of precision-cut slice cultures of human placenta
por: Fahmi, Amal, et al.
Publicado: (2022)

Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice
por: Hiorns, Jonathan E., et al.
Publicado: (2016)

Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices
por: Sadasivan, Satish Kumar, et al.
Publicado: (2014)

Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice
por: Hiorns, Jonathan E., et al.
Publicado: (2017)

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices
por: Hirn, Stephanie, et al.
Publicado: (2014)

Best Practices and Progress in Precision-Cut Liver Slice Cultures
por: Dewyse, Liza, et al.
Publicado: (2021)

Multiscale stiffness of human emphysematous precision cut lung slices
por: Kim, Jae Hun, et al.
Publicado: (2023)

Tamoxifen Affects Aquaporin-3 Expression and Subcellular Localization in Rat and Human Renal Collecting Ducts
por: Tingskov, Stine Julie, et al.
Publicado: (2023)

The Effect of Antifibrotic Drugs in Rat Precision-Cut Fibrotic Liver Slices
por: Westra, Inge M., et al.
Publicado: (2014)

Preserving Airway Smooth Muscle Contraction in Precision-Cut Lung Slices
por: Li, Guang, et al.
Publicado: (2020)

Reduced biomechanical models for precision-cut lung-slice stretching experiments
por: Pybus, Hannah J., et al.
Publicado: (2021)

The Challenge of Long-Term Cultivation of Human Precision-Cut Lung Slices
por: Preuß, Eike B., et al.
Publicado: (2022)

Neuropeptide stimulation of physiological and immunological responses in precision‐cut lung slices
por: Patlin, B., et al.
Publicado: (2023)

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
por: Neuhaus, Vanessa, et al.
Publicado: (2018)

Precision-cut liver slices: a versatile tool to advance liver research
por: Palma, Elena, et al.
Publicado: (2018)

Rat precision-cut liver slices predict drug-induced cholestatic injury
por: Starokozhko, Viktoriia, et al.
Publicado: (2017)

Precision-Cut Tumor Slices (PCTS) as an Ex Vivo Model in Immunotherapy Research
por: Dimou, Paraskevi, et al.
Publicado: (2022)

The Use of Precision‐Cut Lung Slices for Studying Innate Immunity to Viral Infections
por: Michalaki, Christina, et al.
Publicado: (2022)

Functional changes in long-term incubated rat precision-cut lung slices
por: Nußbaum, Sarah Marie, et al.
Publicado: (2022)

RANKL confers protection against cell death in precision-cut lung slices
por: Ruigrok, M. J. R., et al.
Publicado: (2022)

Transcriptomic profiling of induced steatosis in human and mouse precision-cut liver slices
por: Simon, Eric, et al.
Publicado: (2023)

Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct
por: Choi, Hyo-Jung, et al.
Publicado: (2020)

Cardiovascular Agents Affect the Tone of Pulmonary Arteries and Veins in Precision-Cut Lung Slices
por: Rieg, Annette D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_d48u5us8ffmk098jk18hfkg7mo