Structures of ferroportin in complex with its specific inhibitor vamifeport

A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe(2+) transport and induces internalization and degradation of FPN. Dysregulation of the FPN/hepcidin axis leads to diverse path...

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Detalles Bibliográficos
Autores principales: Lehmann, Elena Farah, Liziczai, Márton, Drożdżyk, Katarzyna, Altermatt, Patrick, Langini, Cassiano, Manolova, Vania, Sundstrom, Hanna, Dürrenberger, Franz, Dutzler, Raimund, Manatschal, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030120/
https://www.ncbi.nlm.nih.gov/pubmed/36943194
http://dx.doi.org/10.7554/eLife.83053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030120/
https://www.ncbi.nlm.nih.gov/pubmed/36943194
http://dx.doi.org/10.7554/eLife.83053

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