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Structures of ferroportin in complex with its specific inhibitor vamifeport

A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe(2+) transport and induces internalization and degradation of FPN. Dysregulation of the FPN/hepcidin axis leads to diverse path...

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Detalles Bibliográficos
Autores principales:	Lehmann, Elena Farah, Liziczai, Márton, Drożdżyk, Katarzyna, Altermatt, Patrick, Langini, Cassiano, Manolova, Vania, Sundstrom, Hanna, Dürrenberger, Franz, Dutzler, Raimund, Manatschal, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030120/ https://www.ncbi.nlm.nih.gov/pubmed/36943194 http://dx.doi.org/10.7554/eLife.83053

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