Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds

MGB polyamide-oligonucleotide conjugates ON 1-4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB polyamide binding sequence using T(m) and CD analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamaike, Kazuo, Sano, Mutsumi, Sakata, Daisuke, Nishihara, Yu, Amino, Hiroaki, Ohtsuki, Akihiro, Okada, Yui, Miyakawa, Takafumi, Kogawara, Makoto, Tsutsumi, Mai, Takahashi, Misato, Kawashima, Etsuko, Ota, Koichiro, Miyaoka, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030224/
https://www.ncbi.nlm.nih.gov/pubmed/36960406
http://dx.doi.org/10.1155/2023/2447998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030224/
https://www.ncbi.nlm.nih.gov/pubmed/36960406
http://dx.doi.org/10.1155/2023/2447998

Ejemplares similares