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Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds

MGB polyamide-oligonucleotide conjugates ON 1-4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB polyamide binding sequence using T(m) and CD analy...

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Detalles Bibliográficos
Autores principales:	Kamaike, Kazuo, Sano, Mutsumi, Sakata, Daisuke, Nishihara, Yu, Amino, Hiroaki, Ohtsuki, Akihiro, Okada, Yui, Miyakawa, Takafumi, Kogawara, Makoto, Tsutsumi, Mai, Takahashi, Misato, Kawashima, Etsuko, Ota, Koichiro, Miyaoka, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030224/ https://www.ncbi.nlm.nih.gov/pubmed/36960406 http://dx.doi.org/10.1155/2023/2447998

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