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Binocular dynamic visual acuity in dry eye disease patients

PURPOSE: To investigate binocular dynamic visual acuity (DVA) for patients with dry eye disease (DED). METHODS: The prospective study included DED patients. The binocular DVA at 40 and 80 degrees per second (dps), Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear film break-up ti...

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Autores principales: Ren, Xiaotong, Wang, Yuexin, Wu, Tingyi, Jing, Dalan, Li, Xuemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030492/
https://www.ncbi.nlm.nih.gov/pubmed/36968505
http://dx.doi.org/10.3389/fnins.2023.1108549
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author Ren, Xiaotong
Wang, Yuexin
Wu, Tingyi
Jing, Dalan
Li, Xuemin
author_facet Ren, Xiaotong
Wang, Yuexin
Wu, Tingyi
Jing, Dalan
Li, Xuemin
author_sort Ren, Xiaotong
collection PubMed
description PURPOSE: To investigate binocular dynamic visual acuity (DVA) for patients with dry eye disease (DED). METHODS: The prospective study included DED patients. The binocular DVA at 40 and 80 degrees per second (dps), Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear film break-up time first (TBUTF), corneal fluorescein staining (CFS), eyelid margin abnormalities and meibomian gland (MG) abnormalities morphology and function were evaluated. A deep learning model was applied to quantify the MG area proportion. The correlation between DVA and DED parameters was analyzed. RESULTS: A total of 73 DED patients were enrolled. The age, OSDI, CFS, MG expressibility, secretion quality, and eyelid margin abnormalities were significantly positively correlated with the DVA for 40 and 80 dps (all P < 0.05). The MG area proportion in the upper eyelid was negatively correlated with DVA at 40 dps (R = −0.293, P < 0.001) and at 80 dps (R = −0.304, P < 0.001). Subgroup analysis by MG grade demonstrated that the DVA of patients with severe MG dropout (<25% of the total area) was significantly worse than other mild and moderate groups, both in 40 and 80 dps (all P < 0.05). The patients with CFS showed worse 40 (P < 0.001) and 80 dps (P < 0.001) DVA than the patients without CFS. CONCLUSION: Binocular DVA is significantly associated with DED symptoms and signs. The DED patients with CFS and severe MG dropout and dysfunction have worse DVA.
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spelling pubmed-100304922023-03-23 Binocular dynamic visual acuity in dry eye disease patients Ren, Xiaotong Wang, Yuexin Wu, Tingyi Jing, Dalan Li, Xuemin Front Neurosci Neuroscience PURPOSE: To investigate binocular dynamic visual acuity (DVA) for patients with dry eye disease (DED). METHODS: The prospective study included DED patients. The binocular DVA at 40 and 80 degrees per second (dps), Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear film break-up time first (TBUTF), corneal fluorescein staining (CFS), eyelid margin abnormalities and meibomian gland (MG) abnormalities morphology and function were evaluated. A deep learning model was applied to quantify the MG area proportion. The correlation between DVA and DED parameters was analyzed. RESULTS: A total of 73 DED patients were enrolled. The age, OSDI, CFS, MG expressibility, secretion quality, and eyelid margin abnormalities were significantly positively correlated with the DVA for 40 and 80 dps (all P < 0.05). The MG area proportion in the upper eyelid was negatively correlated with DVA at 40 dps (R = −0.293, P < 0.001) and at 80 dps (R = −0.304, P < 0.001). Subgroup analysis by MG grade demonstrated that the DVA of patients with severe MG dropout (<25% of the total area) was significantly worse than other mild and moderate groups, both in 40 and 80 dps (all P < 0.05). The patients with CFS showed worse 40 (P < 0.001) and 80 dps (P < 0.001) DVA than the patients without CFS. CONCLUSION: Binocular DVA is significantly associated with DED symptoms and signs. The DED patients with CFS and severe MG dropout and dysfunction have worse DVA. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10030492/ /pubmed/36968505 http://dx.doi.org/10.3389/fnins.2023.1108549 Text en Copyright © 2023 Ren, Wang, Wu, Jing and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ren, Xiaotong
Wang, Yuexin
Wu, Tingyi
Jing, Dalan
Li, Xuemin
Binocular dynamic visual acuity in dry eye disease patients
title Binocular dynamic visual acuity in dry eye disease patients
title_full Binocular dynamic visual acuity in dry eye disease patients
title_fullStr Binocular dynamic visual acuity in dry eye disease patients
title_full_unstemmed Binocular dynamic visual acuity in dry eye disease patients
title_short Binocular dynamic visual acuity in dry eye disease patients
title_sort binocular dynamic visual acuity in dry eye disease patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030492/
https://www.ncbi.nlm.nih.gov/pubmed/36968505
http://dx.doi.org/10.3389/fnins.2023.1108549
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