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The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity

PVR (poliovirus receptor) functions as a ligand that signals through TIGIT and CD96 to induce suppression of T-cell and NK-cell responses. Alternatively, PVR binds to CD226, resulting in a co-stimulatory signal. To date, TIGIT antibody antagonists have been developed to restore immune functions and...

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Detalles Bibliográficos
Autores principales:	Saha, Shrayasee, Sparkes, Amanda, Matus, Esther I., Lee, Peter, Gariépy, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030575/ https://www.ncbi.nlm.nih.gov/pubmed/36944702 http://dx.doi.org/10.1038/s41598-023-30999-w

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